The history and developmental advances of beta blockers Essay

The history and developmental advances of beta blockers - Essay Example Drugs exerting antagonistic effects at sympathetic nerve endings are called sympatholytics. Similarly the neurotransmitter of the Parasympathetic system is Acetyl choline. Drugs accordingly are called parasympathomimetics/lytics. Both these neurotransmitters exert their specific action by interacting with target cells on specialized cellular sites called receptors. The original concept of receptor sites was introduced independently by Ehrlich and Langley as early as the late nineteenth century. It is now well established that receptors are part of macromolecular complexes on effector cells with which drug molecules interact to produce effects. Isolation and characterization of receptors has been done by radioligand binding studies. The receptors of the sympathetic system have been broadly classified into ÃŽ ± and ÃŽ ² receptors with further sub classifications. Similarly the receptors of the parasympathetic system have been broadly classified as muscarinic and nicotinic receptors. Me dical interventions have been designed during the course of research in therapy whereby either mimicking or antagonizing the role of these neurotransmitters has been exploited for beneficial effects. ÃŽ ² blockers are the drugs or molecules which block the action of Noradrenalin on the ÃŽ ² receptors which has a very specific role to play in maintaining physiological equilibrium in the body. ÃŽ ² receptors are present throughout specialized cells in the body and play important roles in physiological function. They are predominant in cardiac cells, small coronary vessels, smooth muscles like trachea, bronchi, blood vessels, intestines, vas deferens, liver, diaphragmatic striated muscles, uterus and non innervated tissues like erythrocytes, lymphocytes, mast cells and polymorphonuclear leucocytes. The type of ÃŽ ² receptors in different organs are

The value of liquid based cytology compared to conventional smear in Essay

The value of liquid based cytology compared to conventional smear in fine neddle aspiration of cytology - Essay Example Also termed as Fine Needle Aspiration Cytology (FNAC), it is a simple, quick and inexpensive method used to diagnose superficial surface masses, and is especially useful in sampling the accessible head and neck masses in outpatient department (Pilotti et al 1993). Masses located within the region of the head and neck, including salivary gland and thyroid gland, cervical masses and nodules, and intraoral lesions can be readily diagnosed using this technique. It is the procedure of choice in outpatient departments, especially for the lesion of head and neck. Some of such studies have been considered here to comprehend the differences and efficacies of each of the two techniques FNAC proves to be better than conventional smear in a number of ways. It is relatively safe since it is pretty much noninvasive when it comes to diagnosing malignancies, to which the only alternative before the advent of FNA was open excision biopsy. The most commonly encountered lesions in this area are lumps or swellings. The differential is important to rule out the malignancy, which is the most suspected diagnosis (Lee et al 1987, Skoog et al 2009). The technique is relatively easy to perform, fairly accurate and well tolerated by the patients. It is associated with low morbidity as it causes minimal suffering and carries next to no risk of complications. Its accuracy turns out to be the major reason for its preference over the conventional Pap smear. Numerous studies have been conducted in the area to analyze the advantages and pitfalls of both the techniques. The critical review below will outline various studies and help establish a view point about the two and reveal the superiority of FNAC. 1. Parfitt et al (2007) conducted a research to analyze the accuracy given by the two techniques. CS offers more accurate diagnosis more often. Accuracy offered by CS was 57% as compared to just 42% with that of thinprep. Thinprep has a higher

Management, Personal Relationship and Decision Making Essay Example for Free

Management, Personal Relationship and Decision Making Essay The concept of interpersonal relationships and management involves ideas, taught, and beliefs that are related with social association and affiliations which are employed as approached to marketing, operations, training, management and executive decision (Giddens, 2001). These taught and perceptions constitute different philosophies used by various organizations that create a harmonious place for members and personnel. These beliefs allow the organization’s business to improve. Business improves since personnel performances are able to maximize their potential because people are working perfectly as a team. It is no secret that in order for business to be successful, management plays a very important role (Virine, 2007). Thus, for business to prosper, philosophy in management should be carefully taken into consideration (Virine, 2007).   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚     In order to successfully manage an activity or personnel it is important that a manager is strong-willed, determined and possessed the â€Å"drive† needed to achieve the desired goal.   It is significant that a person should do a specific thing really well. In order to achieve this, a fine plan should be accomplished and when the plan is executed it is necessary that the plan is strictly followed. It is also important that the existing plan can adapt to changes that when problems are encountered, it can easily be resolved. Also in managing, it will be fitting to add that it is not enough that a person would know how to do things correctly, but it would be a welcome addition to recognize that a person knows how to things better.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   A person should understand and put into his mind that there are occasions when great just isn’t good enough. He should not settle for less instead strive and work harder to deliver and perform things way beyond what people have expected. He should not be satisfied by saying â€Å"this will already do† and â€Å"this is alright†. He should always work to be the best. Being the best should not be the endpoint that will mark the conclusion of a venture, but it should be a starting point of something that is great. Through sheer innovation one should take something that works, it could be ideas, or various products such as electric appliances, glassware or simple things like papers and plastics, then transform them and improve them to something that is really unexpected. A person should always try to work to achieve excellence.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   However, in order to properly manage things there are other factors that should be taken into account. One major factor is inter-personal relationship. Relationship with others influences the way we manage things our everyday life (Kahneman, 2000). It is because of our relationship to our love ones that we strive to make things better. It is because of these people who are close to us and we hold dearly in our hearts that we struggle in order to create a better living condition. Because of them we â€Å"shoot for the stars† and aim for the best. Furthermore, our relationship in our workplace with fellow personnel and with the manager dictates the success or the failure of an activity. As mentioned before, it is important to achieve a working area that is surrounded by people which are friendly and are always prepared in lending help. Somehow, they can be your family that during the most challenging times in the work one would have somebody to lean on (Lauria, 1964). They would provide you support and the much needed boost during office hours. With someone to call on, personnel can fully utilize their skills and maximize their talents. Workers do not need to be worry of accidents that may happen, since a sense of security and protection is given to them, as a result they become more focused. Also, in return workers and personnel would work doubly harder to showcase their affection to the people who have helped them in work and their gratitude to the organization and their bosses. Another essential issue that arises from the proper managing of things is decision making. Making a sound decision is hard and when at one point an organization has arrived to a decision, it is always certain that not everyone would be pleased, there would always be contentions. Generally, there are no rules that would make a person a good decision –maker (Plous, 1993). There are always risks that are involved and often times these risks impose immense problems that lead to the downfall of what seems a fair decision at the beginning. There are, however things that can help a person in making decision. Information should first be gathered and accumulated about the issue at hand. Careful study and precautions must be done to properly weigh things. In making a decision it is important to first ask who will be affected once the decision is handed out. Then, we should also understand who will benefit and to whom the decision is detrimental. In making a decision, one should decide for the good of majority and sacrifice his own self interest. To be a good decision maker one needs to be self-less. It is a noble act, a supreme sacrifice. A situation that recently took place in my office is the grudge that happens between two of my colleagues. The conflict occurs because of a misunderstanding for the division of labor in the office. Due to the misunderstanding, a part of the job was left undone. When the deadline arrives and portion of their proposal was still incomplete, pressure started to build up and emotions run high. As a result, a dispute between them existed. For a period of one month or so they started not to talk with each other after their proposal was dumped. Since, both are my friends and I am the one who is being caught from their fight I decided to talk to them and invite them to be part of a project that was assigned to me. Although they were hesitant to work with each other, I convinced them telling they are the most trusted person I knew that could help me and the only person which fitted the job. Professional as they are, they put aside their differences, and worked as a real team. With me calling the shots, and making sure everything is carefully attended and no single detail taken for granted we finished an astonishing job with lots of time to spare. We can infer that by setting aside their argument and their pride for a better cause, and giving each other another chance to work a fine output is achieved. They decided to be selfless and put the organization on top of their priority. References Giddens, A. (2001). Sociology. Cambridge: Polity. Kahneman, D. (2000). Choice, Values, Frames. Cambridge: The Unviersity Press. Lauria, A. (1964). Respeto, Relajo and Inter-Personal Relations in Puerto Rico Anthropological Quarterly, Vol. 3 (No. 2). Plous, S. (1993). The Psychology of Judgement and Decision Making New York: McGraw-Hill. Virine, L. (2007). Management Concepts: Vienna.

Neuropsychologist and Patient Perspectives :: Tumors Cancer Neurology Medical Essays

Neuropsychologist and Patient Perspectives There are many classifications of tumors that compress or destroy the hypothalamus. A few forms are craniopharyngioma, germinoma, and glioma. Symptoms of craniopharyngioma include headaches, visual disturbances, pituitary hormone deficiencies, retardation of growth, and calcification of the sella region in children. Germinoma, also called ectopic pineoloma or atypical teratoma, has similar effects to serninoma of the testis or dysgerminoma of the ovary. Another destructive cancer is glioma of the hypothalamus. Hand-Schuller-Christian disease produces hypopituitarism with delayed puberty, growth retardation, and diabetes insipidus; this type of cancer occurs in children (Yen and Jaffe 1986). Since the hypothalamus regulates release of hormones through the pituitary gland, one of the most common effects of damage to the hypothalamus is disruption of hormone release or hormone deficiency. Some common types of hormone deficiencies are gonadotropin, thyroid stimulating, adrenocorticotopic, growth, multiple, and panhypopituitarism. Gonadotropin deficiency is characterized by low levels of luteinizing hormone and follicle-stimulating hormone. This deficiency can lead to decreased fertility, disrupted menstruation, decreased sex drive, headaches, sexual dysfunction, and loss of body hair. Typical treatment is hormone replacement therapy. Deficiency of thyroid stimulating hormone and subsequent lack of thyroid gland stimulation lead to a condition called hypothyroidism. Common symptoms include intolerance to cold, weight gain, constipation, fatigue, and pale, waxy skin. Before hormone replacement is used to stimulate the thyroid, it is typical to try treating the adrenal glands with steroids. Adrenocorticotopic hormone deficiency is the name for low levels of corticotropin (ACTH), a hormone that stimulates the adrenal gland to produce cortisol. Some signs of ACTH deficiency are low blood pressure, weakness, fatigue, weight loss, and in women nausea, pale skin, and loss of pubic hair. Daily doses of hydrocortisone or cortisone are used to correct this deficiency. Deficiency of growth hormone before physical maturity will impair growth, and in adults may be noticeable by obesity or skin wrinkling. Careful doses of growth hormone are administered to children with this condition and in adults may help restore the healthy muscle to fat ratio. Multiple hormone deficiency is more common than deficiency of a single hormone and usually loss occurs in a specific order: first growth, then luteinizing, follicle- stimulating, thyroid stimulating, and adrenocorticotopic. This process is typically slow and occurs over months and years, but hypopituitarism can start suddenly as in the case of traumatic brain injury. Panhypopituitarism is the loss of all hormones released by the pituitary, also called complete pituitary failure.

Burning a Nation’s Flag: Hate Crime

Burning a nation's flag: Hate Crime or Free Speech? A nation's flag is one of the most important things to a country. Citizens of a nation use it during special ceremonies, and a nation's flag is displayed all over that nation. A flag is an emblem shown as a symbol of unity. It symbolizes the pride and history of a nation. So what does burning a nation's flag mean? Is it considered a hate crime and illegal, or is it considered an act of free speech and protected by the First Amendment?For the purposes of this argument, a hate crime is defined as a crime motivated by racial, sexual, or other prejudice, typically one involving violence (What Are Hate Crimes? ). I believe that burning a nation's flag is not a hate crime due to the fact that burning a nation's flag falls under a category that is protected by the First Amendment. In a hate crime, the targeted group could be categorized by not just race or sexuality, but religion and political beliefs or group as well. By burning a nation' s flag, we could easily categorize it as targeting a political group.When a person burns a nation's flag, he/she could be targeting the general people of that nation, the government of that nation, or to be even more specific, the leaders of that government. . In this case, we will say that the political group referred to is the government(to be more specific, the American government). Therefore, by burning a nation's flag, someone disagrees and takes a stand against a political activity or decision. In contrast to what a hate crime is, an act of free speech, protected by the First Amendment, is the right to express any opinions without censorship or restraint.An act of free speech does not necessarily mean saying something out loud. It could also mean expressing your opinions about something by using actions. Since burning a nation's flag suggests taking a stand against a political activity, it is a way of expressing your opinion. Similar to free speech, freedom of expression which is part of the Human Rights Act says that you have the right to hold your own opinions and to express them freely without government interference (Equality and Human Rights Commission).The government cannot arrest you or punish you for burning a nation's flag as long as no one gets physically hurt. Just like in almost every country around the world, America has its own Flag Code. The Flag Code is a guide for all handling and display of the Stars and Stripes, but it does not impose penalties for misuse of the United States flag (US code 36). Each state has its own flag law, and penalty for misuse of the flag is up to the state. Criminal penalties for certain acts of vandalism of a flag were stated in Title 18 of the United States Code prior to 1989.The Supreme Court decision in Texas v. Johnson held the statute unconstitutional, though. In Texas v. Johnson, respondent Gregory Lee â€Å"Joey† Johnson was convicted of an act of disrespect of a venerated object, which violates a Texas statute. During the 1984 Republican National Convention, Johnson protested the policies of the Reagan administration and Dallas-based corporation. During the protest, Johnson burned the American flag. No one was physically hurt or injured, but some witnesses felt severely offended by this.However, due to the First Amendment, the Texas Court of Criminal Appeals decided that the State could not punish Johnson for burning the flag in these circumstances. In addition, the Texas statute states that it is only illegal to burn a nation's flag when the act would result in a serious disturbance of peace. However, the flag burning in this case did not threaten such a reaction (Texas v. Johnson. ). It is true that showing your anger towards the government can be expressed in other ways besides burning the nation's flag.One could protest, write a book, or write a blog to take a stand against a political action. However, no matter which of these actions you decide to do, you are still doi ng it to achieve the same goal: express your opinion and make a change in the government. Citation Page â€Å"Texas v. Johnson. †Ã‚  Cornell University Law School. 21 Mar. 1989. Online. 12 Feb. 2013. ;http://www. law. cornell. edu/supct/html/historics/USSC_CR_0491_0397_ZS. html;. â€Å"What Are Hate Crimes? †Ã‚  SikhNet. Online. 12 Feb. 2013. ;http://fateh. sikhnet. com/s/HateCrimeInfo;. â€Å"Article 485†Ã‚  New York Laws. Online. 12 Feb. 2013.

Fourth Amendment 4th Amendment - 1596 Words

The 4th amendment, search and seizure causes a lot of problems. Search and Seizure is the rights that police have when they enter in a home. The standard for conducting a warrantless search, probable cause, is the same standard necessary for a warrant to issue. An illegal search or illegal seizure is a violation of your Fourth Amendment rights, and any evidence seized must be excluded from trial. Normally police need a search warrant to enter into a home unless they get the consent to enter in the home without one they normally dont go go into a home without anything. A terry pat is when a police officer can detain or conduct a reasonable search for weapons where the officer has the reason to believe the person is armed. Auto stops is†¦show more content†¦Although commonly referred to as the â€Å"automobile exception,† this rule applies to any vehicle, including boats. While in some ways, it is quite a broad exception, this rule limits the ability to search those are as that might contain evidence of the type suspected to be present. In other words, if police suspect that the occupant of a boat is smuggling people across the border, searching a small tackle box on board would not be permissible. However, if they were looking for drugs, they could search the tackle box. The rationale is that, if an officer has to take the time to obtain a warrant, the vehicle might be out of reach before the warrant can be issued and executed. The rationale here is similar to the automobile exception. Evidence that can be easily moved, destroyed or otherwise made to disappear before a warrant can be issued may be seized without a warrant. Furthermore, if a suspect enters private property while being pursued by officers, no warrant is required to enter that property in order to continue pursuit, even if the suspect is in no way connected with the property owner. No warrant is required to seize evidence in plain view if the police are legitimately in the location f rom which the evidence can be viewed. For example, an officer cannot illegally enter a suspect’s backyard and then use the plain view exception to seize an illegally kept alligator living in the pool. But, if on the premises to serve a warrant duly issued to search for marijuanaShow MoreRelatedThe Dangers Of The 4th Amendment And The Fourth Amendment1610 Words   |  7 PagesThe Fourth Amendment in the Bill of Rights ensures Americans the right to be secure in their homes from government intrusion. Essentially, an officer cannot enter the place of residence of an individual without probable cause or a search warrant. However, with the advances in technology, the government is able to use GPS technology to gain information on certain criminal prospects without probable cause. This is considered unlawful in regards to what the Fourth Amendment stands for. 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The Future Of Health Care - 833 Words

The future of health care can be rocky with the push to mandate population health and bundle payments as the standard measure for future reimbursement. The ACA, increasing cost of health care and mortality rates are the driving force. Although population health and bundle payments are voluntary programs at this time, it will become the standard of care model in the future. Although population health has been associated with ACOs and the MSSP programs, the future reimbursement model for health care goes beyond these programs as more and more insurance companies are pushing for quality care and reduction in cost. In addition, CMS is leading the charge to increase bundled payment models. In regards to bundled payments there is a growing momentum and as of August 5, 2014 approximately 2,368 new potential participants joined Phase one and new episodes will be added until October 2015 and more episodes will be added to additional models and phases along with the patient survey to evalua te the patient’s experience therefore CMS is expecting the program to continue to expand throughout the market (CMS: Bundled Payment for Care Improvement Initiative (BPCI) Fact Sheet, 2015). Therefore these two models that are voluntary today are moving toward being the stand of tomorrow. The concept of population health is patient centric and is making inroad throughout the country and is broadly defined as a systematic effort to do three things that the U.S. health care system and its â€Å"utilize†Show MoreRelatedThe Future And Direction Of Health Care1269 Words   |  6 PagesThe future and direction of health care has been the topic of discussion amongst politician and U.S citizens today. There are several challenges surrounding the future and strategic direction in which health care should be heading. Accreditation, quality of health care and organization’s compliance; access to health care, maintaining a skilled workforce, information technology and pay for performance are some of the challenges that currently presenting itself in healthcare today. If health care isRead MoreFuture Direction of Health Care1442 Words   |  6 PagesThere are many challenges that are defining the future strategic direction of health care such as information technol ogy advancements, access to health care, maintaining a skilled workforce, proposed health care reform and legislation, and rising costs. I will look at these challenges and how an organization may adapt its direction and strategies in accordance with these challenges. The Affordable Care Act of 2010 marks a new era in American health care. Yet in many ways, this era began more than aRead MoreFuture Trends in Health Care1337 Words   |  6 PagesFuture Trends in Health Care HCS/533 November 29, 2010 Future Trends in Health Care Personal face-to-face communication is and will continue to be the foundation of the patient- physician relationship. 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Advancing technology also pushes the boundaries of health care in its ability to integrate health care information. The integration of health care information is critical to the effective, efficient delivery of quality care in a now fragmented health care system. This paper will assess how the internet orRead MoreHow Health Care will Change in the Future1056 Words   |  4 Pagesability to soar in the future. What would the healthcare system look like? What ideas would we bring back from the future and place into practice? According to Murphy (2011) leaders will begin to â€Å"lead from the future† (p. 26). In 2009, President Barack Obama signed the HITECH Act legislation. The legislation supports the adoption of meaningful use of information technology (U. S. Department of Health Human Service, 2013). 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